![]() Genes required for survival in microgravity revealed by genome-wide yeast deletion collections cultured during spaceflight. Gene pathways analysis of the effects of suspension culture on primary human renal proximal tubular cells. Mechanical culture conditions effect gene expression: Gravity-induced changes on the space shuttle. Maintenance of liver functions in rat hepatocytes cultured as spheroids in a rotating wall vessel. Analysis of gene and protein expression of cytochrome P450 and stress-associated molecules in rat liver after spaceflight. Effects of spaceflight on innate immune function and antioxidant gene expression. Is spaceflight-induced immune dysfunction linked to systemic changes in metabolism? PLoS ONE 2017, 12, e0174174. Spaceflight Activates Autophagy Programs and the Proteasome in Mouse Liver. Spaceflight and simulated microgravity cause a significant reduction of key gene expression in early T-cell activation. Bioconductor: Open software development for computational biology and bioinformatics. The authors have no financial conflicts of interest to declare. , but did not reach statistical significance. In our data, HSP90 and p53 gene expression were decreased in the flight group similar to the observations of Baba et al. ![]() in the rotating wall vessel, that rat hepatocytes maintained CYP functions and albumin production for more than 30 days in suspension culture. This is consistent with the finding of Brown et al. From our data, we can confirm a large increase in hepatic CYP4A1 during spaceflight, as 47 other hepatic CYPs did not change in space. ![]() Combined with histology, it was concluded that the effects of spaceflight on the liver may be similar to mild cold stress or fasting. The gene and protein expression of stress-related proteins CYP4A1and Cirp gene expression was significantly increased whereas HSP90 and p53 gene expression was significantly decreased in the flight group than in the ground control. analyzed gene and protein expression of 11 cytochrome P450s and stress-associated molecules in liver tissue from male Sprague–Dawley rats, aged 65 days at launch and flown in space for nine days. ![]()
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